CURRENT
research
Current
Research
Clinical Trials are conducted at VOSM in Annapolis Junction, MD. In order for an animal to participate in a clinical trial they must meet the general inclusion criteria and the specific qualifications for each study. To get involved with with any of the studies below, please contact Jeff Curry, research technician, at (240) 295-4400 or jcurry@vosm.com.
General Inclusion Criteria:
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Dog of any breed
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Between the ages of 2 and 12 years
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Minimum weight of 25 pounds
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Medically suitable for sedation or general anesthesia
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No history of malignancy
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Complete history and physical examination
Librela Osteoarthritis Pain Management Study
Zoetis Librela (TM) is an FDA-approved monoclonal antibody treatment for canine OA pain, administered monthly according to the animal's weight via subcutaneous injection.
The product has been used in Europe and Canada since 2021 and was made available in the USA in late 2023.
The purpose of this study is to evaluate the efficacy of Zoetis Librela in canines over a period of 90 days using objective outcome measures including objective gait analysis and owner-reported CBPI pain index survey
Side effects from this clinical trial are unlikely but could include joint infection, pain post-injection, lack of clinical improvement of symptoms, and risks associated with sedation. Most patients are able to participate in this clinical trial without sedation, and discomfort (if present) typically subsides within a day or two of the injection.
Study qualifications are listed below.
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Dogs must weigh 40 - 100 lbs
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Dogs must have a diagnosis of elbow, shoulder, stifle or hip (osteo)arthritis
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Dogs must have history and be able to participate in a physical exam
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Dog must not have any medical conditions which will interferes with their ability to comply with the protocol or interpretation of study results (that is neurological disease, hypothyroidism, dermatitis, diabetes, cancer, pregnancy, lactating)
The length of this clinical trial is 90 days. Patients will have rechecks (~1 hour) scheduled for days 14, 30, 60, 90 post enrollment. Owners will be asked to complete a brief CBPI (pain measurement) validated survey, the dog's gait will be evaluated as well as goniometric measurement of the affected joints. This is a placebo-controlled study; On day 0 ten patients will receive an injection of the product and 10 will only appear to have received an injection. On day 90 patients that did not receive an injection prior will receive an injection of the product; patients that received an injection on day 0 will only appear to have received an injection on day 90. Owners and doctors will not be unblinded until the end of the study unless it is required for patient health and safety.
If you are interested in participating in the new clinical trial, please email Jeff Curry, jcurry@vosm.com.
Recent Publications
Turner K, Canapp S, Canapp D, Sutton A, Canapp A, Jimenez I, Gerardi, J. Client-based evaluation of the effects of localized vibration therapy on pain and mobility scores in dogs with radiographic bilateral hip dysplasia. Front. Vet. Sci., 20 August 2024; Sec. Anesthesiology and Animal Pain Management. August 2024
Sack D, Canapp D, Canapp S, Majeski S, Curry J, Sutton A., Cullen R. Iliopsoas strain demographics, concurrent injuries and grade determined by musculoskeletal ultrasound in 72 agility dogs. Canadian Journal of Veterinary Research. July 2023
Helen Tsoi, Debra A, Canapp, Sherman O. Canapp. Ultrasonographic detection of cranial cruciate ligament pathology in canine stifles without cranio-caudal instability. Veterinary Evidence. March, 2023
Isabel A Jimenez, Sherman O. Canapp, Monica L Percival. Internet-Based Survey Evaluating the Impact of Ground Substrate on Injury and Performance in Canine Agility Athletes. Frontiers in Veterinary Science. October, 2022.
Tiojala TM, Canapp DA, Canapp SO. Ultrasonic Finding in the Proximal Sciatic Nerve and Deep Gluteal Muscles in 29 Dogs With Suspected Sciatic Neuritis. Frontiers in Veterinary Medicine. August, 2021
Chun N, Canapp S, Carr BJ, Wong V, Curry J. Validation and Characterization of Platelet-Rich Plasma in the Feline: A Prospective Analysis. Frontiers in Veterinary Science. August 2020.
Tsoi H, Canapp S, Ferrell J. The use of Needle Scope Technology for the Treatment of
Shoulder, Elbow and Stifle. Intra-articular Conditions Compared to standard
Arthroscopy. Journal Of Veterinary Surgery, In review.
Stokes R, Canapp DA, Canapp SO, Ferrell J. Evaluation of Carpal Injuries with
Diagnostic Musculoskeletal Ultrasound in the Canine. Journal of the American
Veterinary Medicial Association. In review.
McDougal RA, Canapp SO, Canapp DA. Ultrasonographic Findings in 41 Dogs Treated
with Bone Marrow Aspirate Concentrate and Platelet-Rich Plasma for a Supraspinatus
Tendinopathy: A Retrospective Study. The Journal of Veterinary Regenerative Medicine. Frontier Vet Sci. May, 2018.
Carr BJ, Canapp SO, Chun N. Clinical Efficacy of Platelet Rich Plasma for the
Treatment of Elbow Osteoarthritis in Twenty Dogs. VCOT, July 2018.
Fox E, Dycus D, Leasure C, Canapp S. Average Tibial Plateau Angle of 3,922 Stifles
Undergoing Surgical Stabilization for Cranial Cruciate Ligament Rupture. VCOT, Jul
2018.
Recent Projects
2020 - Present: Centre Hospitalier Vétérinaire Frégis – Arcueil, France Veterinary Orthopedic and Sports Medicine Group – Annapolis Junction, MD Advisor: Guillaume Ragetly, DVM, PhD, DACVS, DECVS
Project: Multicenter study on the arthroscopic management of osteochondritis dissecans lesions of the tibiotarsal joint in dogs.
2020 - Present: Veterinary Orthopedic and Sports Medicine Group – Annapolis Junction, MD Advisor: Sherman Canapp, DVM, MS, CCRT, DACVS, DACVSMR
Project: Injuries in sporting dogs.
2019 - Present: Veterinary Orthopedic and Sports Medicine Group – Annapolis Junction, MD Advisors: Sherman Canapp, DVM, MS, CCRT, DACVS, DACVSMR & Debra Canapp, DVM, CCRT, CVA, DACVSMR
Project: Incidence of medial and lateral collateral ligament pathologies in cranial cruciate ligament deficient stifles as detected on musculoskeletal ultrasound.
2019 - Present: Veterinary Orthopedic and Sports Medicine Group – Annapolis Junction, MD
The use of Needle Scope Technology for the Treatment of Shoulder, Elbow and Stifle Intra-articular Conditions compared to standard Arthroscopy
2019 - Present: Veterinary Orthopedic and Sports Medicine Group – Annapolis Junction, MD
The use of regenerative medicine for the treatment of carpal injuries in sporting and working dogs
2019 - Present: Veterinary Orthopedic and Sports Medicine Group – Annapolis Junction, MD
The use of regenerative medicine for the treatment of caudal cruciate ligament injuries in sporting and working dogs
2017 - 2019
Clinical Efficacy of Dasuquin Advanced for the Treatment of Elbow Osteoarthritis Pain in 20 Dogs
2016 - 2019
Bone Marrow Aspirate Concentrate Pure canine validation study. Collaboration with the University of Maryland, School of Biomedical Engineering
2017 - 2019
The use of pulse magnetic field therapy for the treatment of osteoarthritis in dogs
2017 - 2021
OsteoBioscaff for the treatment of elbow OA in the canine