CURRENT

research

Current

Research

 

Clinical Trials are conducted at VOSM in Annapolis Junction, MD. In order for an animal to participate in a clinical trial they must meet the general inclusion criteria and the specific qualifications for each study. To get involved with with any of the studies below, please contact Jeff Curry, research technician, at (240) 295-4400 or jcurry@vosm.com.

General Inclusion Criteria:

  • Dog of any breed

  • Between the ages of 2 and 12 years

  • Minimum weight of 25 pounds

  • Medically suitable for sedation or general anesthesia

  • No history of malignancy

  • Complete history and physical examination

Gelatin Scaffold

Gelatin Scaffold is an engineered collagen bioscaffold that has been reported to reduce the pain associated with osteoarthritis.  It is thought that Gelatin Scaffold works by providing a pathway for cell proliferation, differentiation, and integration that may help to improve cartilage repair and function in the location of the injection. It is created from a highly purified derivative of porcine collagen. Two promising pilot studies which included 14 dogs in total have already been performed at VOSM and we are currently seeking candidates for a larger crossover study.

Side effects from this clinical trial are unlikely but could include joint infection, pain post-injection, lack of clinical improvement of symptoms, and risks associated with sedation. Most patients are able to participate in this clinical trial without sedation, and discomfort (if present) typically subsides within a day or two of the injection.

 

Study qualifications are listed below.

  • Dogs must weigh 40 - 100 lbs

  • Dogs must have a diagnosis of elbow, shoulder, stifle or hip (osteo)arthritis

  • Dogs must have history and be able to participate in a physical exam

  • Dog must not have any medical conditions which will interferes with their ability to comply with the protocol or interpretation of study results (ex. neurological disease, hypothyroidism, diabetes, cancer, pregnancy.)

 

The length of this clinical trial is 180 days. Patients will have rechecks (~1 hour) scheduled for 14, 30, 60, 104, 120, 150, 180 days post enrollment.  This is a placebo controlled study; on day 0 ten patients will receive an injection of the product and 10 will only appear to have received an injection. On day 90 patients that did not receive an injection prior will receive an injection of the product; patients that received an injection on day 0 will only appear to have received an injection on day 90. Owners and doctors will not be unblinded until the end of the study unless it is required for patient health and safety. 

 

If you are interested in participating in the new clinical trial and helping us to make this product available in the future for other dogs suffering from arthritis please email Jeff Curry, jcurry@vosm.com.

Stifle Osteoarthritis Bio Marker

 

 

 

 

 

 

 

 

 

 

We have partnered with a biotech company in an effort to characterize immunologic and inflammatory biomarker changes in dogs with confirmed stifle osteoarthritis. We are seeking a total of 50 dogs with diagnosed CCL injuries and OA who are interested in TPLO procedures. During the procedure we would like to retain samples of blood, synovial fluid, and synovial membrane for submission to an independent lab at the end of collection. These samples may be collected with no negative impact on the procedure itself or recovery prospects afterwards. Eligible patients are at least 18kg (40lbs) in weight, at least one year in age, and do not have histories of recent surgery or corticosteroid use, or history of non-orthopedic disease. There are no additional cost or time obligations from owners aside from those associated with the TPLO procedure itself. If you are interested in learning more about the study please contact Jeff Curry, jcurry@vosm.com. 

2019 - Present

The use of Needle Scope Technology for the Treatment of Shoulder, Elbow and Stifle Intra-articular Conditions Compared to standard Arthroscopy. 

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2019 - Present

The Use of Regenerative Medicine for the Treatment of Carpal Injuries in Sporting and Working Dogs

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2019 - Present

The Use of Regenerative Medicine for Caudal Cruciate Ligament Injuries in Sporting and Working Dogs

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2017 - Present

Clinical Efficacy of Dasuquin Advanced for the Treatment of Elbow Osteoarthritis Pain in 20 Dogs

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2016 - Present

Bone Marrow Aspirate Concentrate Pure canine validation  study.  Collaboration with the University of Maryland, School of Biomedical Engineering

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2017 - Present

The use of pulse magnetic field therapy for the treatment of osteoarthritis in dogs

2017 - Present

OsteoBioscaff for the treatment of elbow OA in the canine

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© 2019 Orthobiologics

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